The Agilent/Keysight E1421B is a C-size, 6-slot VXI mainframe engineered for compact test and measurement systems requiring cost-effective modular integration. Compliant with VXIbus Specification Revision 1.4, this mainframe delivers 450 W maximum usable power at 55°C across multiple supply rails and accommodates modular instrumentation through P1 and P2 backplane connectors. The Keysight Pressurized Air Channel cooling system maintains uniform thermal distribution, with airflow entering the right side and exhausting left, supporting 60 W per slot at 10°C rise or up to 75 W at 15°C rise. Input power accepts automatic voltage ranging from 100–240 Vac at 50–60 Hz, or 100–120 Vac at 400 Hz. The QUIC module insertion system enables rapid card installation and removal without tools.
Technical Specifications
• VXIbus Compliance: Revision 1.4
• Mainframe Size: C-Size, 6 slots
• Backplane Connectors: P1 and P2
• Maximum Power: 450 W @ 55°C
• Input Power: 100–240 Vac ±10% (50–60 Hz); 100–120 Vac ±10% (400 Hz)
• Inrush Current: 40 A maximum
• Supply Rails: +5 V (45 A peak / 5 A dynamic), +12 V (8 A peak / 2.5 A dynamic), -12 V (8 A peak / 2.5 A dynamic), +24 V (8 A peak / 4 A dynamic), -24 V (8 A peak / 4 A dynamic), -5.2 V (40 A peak / 5 A dynamic), -2 V (15 A peak / 3.5 A dynamic)
• Cooling Capacity: 60 W per slot (10°C rise); 75 W per slot (15°C rise)
• Operating Altitude: 1,500 m
– Key Features
• Pressurized Air Channel cooling with temperature-controlled fan operation
• Over-temperature, over-voltage, over-current, and short-to-ground protection on all outputs
• ACFAIL* and SYSRESET* signal generation per VXI specification
• Rear-panel intake and serviceable power supply
• Compact footprint: 221.5 mm H × 425.5 mm W × 558.8 mm D (without feet)
• Weight: 13.9 kg
– Typical Applications
Portable and rack-mount test systems requiring modular instrument integration with space and power constraints.
– Compatibility & Integration
Accepts all VXI instruments compliant with Revision 1.4 specification. QUIC insertion system supports rapid module deployment in field and lab environments.

















