The National Instruments PCIe-6351 is a high-performance X Series multifunction data acquisition card engineered for demanding measurement and control applications. This PCIe-based device delivers 1.25 MS/s single-channel sampling on 16 analog inputs (8 differential) with 16-bit resolution, plus dual 16-bit analog outputs and 24 digital I/O lines. Advanced onboard NI-STC3 timing technology provides independent analog and digital engines with retriggerable measurement tasks, analog and digital triggering, and four 32-bit counters running at 100 MHz for PWM, encoder, and frequency applications.
Technical Specifications
Analog Input: 16 single-ended or 8 differential channels; 16-bit resolution; 1.25 MS/s single-channel maximum, 1.00 MS/s aggregate multichannel rate; ±0.1 V to ±10 V input ranges; >10 GΩ || 100 pF input impedance; 100 dB CMRR (DC to 60 Hz); 1.7 MHz small-signal bandwidth (-3 dB); 2,047-sample input FIFO; settling time 1–1.5 µs depending on range; ±11 V maximum working voltage.
Analog Output: 2 channels; 16-bit resolution; 2.86 MS/s update rate; ±10 V and ±5 V ranges; 0.2 Ω output impedance; ±5 mA output drive; ±25 V overdrive protection.
Digital I/O: 24 lines at maximum 10 MHz rate.
Counters/Timers: Four 32-bit channels; 100 MHz timebase; PWM, encoder (non-quadrature, 1X/2X/4X quadrature), frequency, and event counting; one frequency generator with 20 MHz, 10 MHz, and 100 kHz base clocks.
Triggers: Analog and digital; external digital via PFI or RSTI; analog sources include AI and APFI 0; functions: start, reference, pause, sample clock, convert clock, and sample clock timebase.
Interface: PCI Express; single 68-pin VHDCI connector; NI-DAQmx driver; onboard PLL; meets EMC standards.
– Key Features
• 16-bit resolution across analog I/O for precise measurement and control
• Dual-channel analog output with 2.86 MS/s update capability
• Four independent 32-bit counters for timing-critical applications
• Configurable analog input ranges from ±0.1 V to ±10 V
• High input impedance and excellent CMRR for noise-sensitive measurements
• Flexible trigger architecture supporting analog and digital sources
– Typical Applications
Process control; sensor measurement and logging; signal generation; timing and synchronization; encoder-based motion feedback; frequency and event counting; multi-channel data streaming over PCIe.
– Compatibility & Integration
NI-DAQmx driver enables integration with LabVIEW, C/C++, Python, and .NET environments. PCI Express connectivity provides high-throughput performance optimized for multicore processor systems.

















